High-Protein Spinach and Artichoke Chicken Casserole Recipe

If you’re craving a comforting, nutrient-packed dish that feels like a warm hug on a plate, you absolutely need to try this High-Protein Spinach and Artichoke Chicken Casserole. This casserole brilliantly combines tender chicken, creamy cottage cheese, savory artichokes, and vibrant spinach, delivering a flavor explosion while packing an impressive protein punch. Whether you’re meal prepping for the week or serving something special for dinner, this recipe balances wholesome ingredients with indulgent layers of cheese and spices to satisfy both your taste buds and your body.

Ingredients You’ll Need

Gathering your ingredients for this High-Protein Spinach and Artichoke Chicken Casserole is a breeze, and each one plays a crucial role in building the casserole’s rich layers of flavor and texture. From the creamy cottage cheese that adds moisture and protein, to the vibrant spinach and tangy artichokes injecting freshness, every component works in delicious harmony.

• 16 oz cottage cheese (4% preferred): Adds creamy texture and a boost of high-quality protein that keeps this dish hearty without heaviness.
• 2 garlic cloves peeled: Provides a fragrant depth that wakes up every ingredient with its unmistakable savory aroma.
• ½ tsp kosher salt: Essential for seasoning the cottage cheese mixture and intensifying all the flavors in the dish.
• ¼ tsp black pepper: Adds a subtle kick that balances the mild creaminess.
• ¼ tsp onion powder: Enhances the savory notes without overpowering the other ingredients.
• 1 tsp avocado oil or olive oil: Perfect for sautéing chicken while keeping it juicy and tender.
• 1 lb boneless, skinless chicken breast, cut into bite-sized pieces: The star protein, tender and satisfying, makes this casserole filling and nutritious.
• Kosher salt and black pepper to taste: For seasoning the chicken and adjusting flavors as you go.
• ½ cup low-moisture, part-skim, finely shredded mozzarella cheese: Melts beautifully to create a luscious, cheesy crust.
• ⅔ cup finely grated parmesan cheese: Gives a sharp, nutty flavor and helps brown the top for that irresistible look and taste.
• 1 can artichoke hearts (16 oz), drained and chopped: Brings a subtle tang and a tender bite that pairs perfectly with the spinach.
• 6 oz frozen chopped spinach, thawed and thoroughly drained: Adds vibrant color, nutrition, and a mild earthiness essential for this classic flavor combo.

How to Make High-Protein Spinach and Artichoke Chicken Casserole

Step 1: Prep the Chicken

This step is key to building intense flavor and ensuring tender chicken. If you have time, sprinkle the bite-sized chicken pieces generously with kosher salt and let them sit at room temperature for about 20 minutes. This dry brine enhances juiciness and flavor. Then, heat your chosen oil in a pan over medium heat and cook the chicken without crowding the pan. Season with black pepper and cook until almost done, about 2-3 minutes per side. Set aside while you prepare the other ingredients.

Step 2: Prepare the Veggies

Drain and chop the canned artichoke hearts to avoid excess moisture, which could make the casserole watery. Using a clean dish towel or cheesecloth, squeeze out any extra liquid from both the artichokes and thawed spinach. This prevents sogginess and concentrates their flavors for the best results.

Step 3: Blend the Cottage Cheese Mixture

Add the cottage cheese, garlic cloves, salt, pepper, and onion powder to a food processor. Blend until completely smooth and creamy. This mixture acts as a rich, cheesy binder that brings everything together with a luscious texture and subtle flavor, setting this casserole apart from the usual spinach artichoke dishes.

Step 4: Combine Ingredients in Baking Dish

In a large baking dish, combine the cooked chicken, drained spinach, chopped artichokes, blended cottage cheese mixture, and about two-thirds of both the shredded mozzarella and grated parmesan cheeses. Mix gently with a spatula until everything is evenly incorporated. Then, spread the mixture out evenly, making sure the layers are nicely distributed for perfect baking.

Step 5: Bake to Perfection

Cover the casserole with foil and bake at 350°F for 20 minutes to meld the flavors and cook the ingredients through. After that, remove the foil and sprinkle the reserved mozzarella and parmesan cheeses on top to form a golden, bubbly crust. Bake uncovered for an additional 10 minutes, and if you want that golden brown finish, pop it under the broiler for a few minutes—just watch carefully so it doesn’t burn!

How to Serve High-Protein Spinach and Artichoke Chicken Casserole

Garnishes

Sprinkle fresh parsley or basil on top just before serving to add a pop of color and a fresh herbal note that complements the richness of the casserole. A squeeze of fresh lemon juice over each serving also brightens the flavors beautifully and adds a zesty twist.

Side Dishes

This casserole is so filling and rich it can easily stand alone. However, a crisp green salad with a light vinaigrette or roasted seasonal vegetables make perfect low-carb sides to complete your meal. For those wanting some carbs, a side of garlic bread or quinoa works wonderfully to soak up the creamy sauce.

Creative Ways to Present

Serve individual portions in cute ramekins for a charming presentation that’s perfect for dinner parties or meal prep. Alternatively, turn this classic casserole into stuffed peppers or even use it as a filling for a savory pie crust when you want to try something a little different with your High-Protein Spinach and Artichoke Chicken Casserole.

Make Ahead and Storage

Storing Leftovers

Leftovers should be covered tightly and refrigerated within two hours of cooking to maintain freshness. Stored in an airtight container, they will stay delicious for up to 3-4 days, making it a convenient option for next-day lunches or quick dinners.

Freezing

You can freeze portions of this casserole for up to 3 months. It’s best to freeze it before baking or immediately after it has cooled post-baking. Use freezer-safe containers or wrap tightly with foil and plastic wrap to protect against freezer burn and preserve the casserole’s flavors and texture.

Reheating

Reheat your frozen or refrigerated casserole in the oven at 350°F until warmed through, about 20-25 minutes for refrigerated leftovers and closer to 40 minutes for frozen. Cover with foil to prevent drying out, then uncover in the last few minutes to refresh the cheesy crust. Microwaving works well for single servings but may soften the crispy top.

FAQs

Can I use fresh spinach instead of frozen?

Absolutely! Fresh spinach will work beautifully; just be sure to sauté or wilt it down first and squeeze out as much liquid as possible to avoid excess moisture in the casserole.

Is this casserole low-carb?

Yes! Thanks to the lean chicken, cottage cheese, and veggies, this High-Protein Spinach and Artichoke Chicken Casserole is naturally low in carbs, making it a great fit for low-carb or keto-friendly diets.

Can I substitute the cottage cheese?

You can substitute ricotta cheese or Greek yogurt if you prefer, but cottage cheese keeps the dish protein-packed and creamy while adding a unique tang that complements the artichokes perfectly.

What if I don’t have a food processor?

No worries! You can mash the cottage cheese and garlic together with a fork or whisk vigorously to achieve a creamy consistency. The mix might be a bit chunkier but will still deliver delicious results.

How can I make this casserole spicier?

Add a pinch of red pepper flakes to the cottage cheese blend or sprinkle some on top before baking. You can also mix in diced jalapeños for an extra kick. Balancing spice with the creamy elements creates an exciting flavor profile.

Final Thoughts

This High-Protein Spinach and Artichoke Chicken Casserole quickly became one of my absolute favorite dinners to make when I want something that feels indulgent but fuels my body at the same time. The creamy, cheesy layers, tender chicken, and fresh veggies make every bite a delight, and the high-protein content keeps you full and satisfied longer. I encourage you to give it a try and discover your new go-to casserole recipe that feels like a warm, nourishing celebration on your plate!

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